Insulin-like growth factor-II mRNA binding protein-3 and podoplanin expression are associated with bone invasion and prognosis in oral squamous cell carcinoma

YS Hwang, SY Ahn, S Moon, Z Zheng, IH Cha… - Archives of oral …, 2016 - Elsevier
Objective This study aimed to evaluate the prognostic implications of insulin-like growth
factor-II mRNA binding protein-3 (IMP3) and podoplanin (PDPN) as therapeutic targets
against oral squamous cell carcinoma (OSCC) with bone invasion. Study design We
elucidated the correlation of IMP3 and PDPN expression with bone invasion in 160 OSCC
tissue specimens, and assessed a mouse calvarium xenograft model using an IMP3-and
PDPN-depleted OSCC cell line. Results The retrospective analysis revealed that the …