[HTML][HTML] SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity
CA Taylor, S Hutchens, C Liu, T Jursa… - Journal of Biological …, 2019 - ASBMB
The essential metal manganese becomes neurotoxic at elevated levels. Yet, the
mechanisms by which brain manganese homeostasis is regulated are unclear. Loss-of-
function mutations in SLC30A10, a cell surface–localized manganese efflux transporter in
the brain and liver, induce familial manganese neurotoxicity. To elucidate the role of
SLC30A10 in regulating brain manganese, we compared the phenotypes of whole-body
and tissue-specific Slc30a10 knockout mice. Surprisingly, unlike whole-body knockouts …
mechanisms by which brain manganese homeostasis is regulated are unclear. Loss-of-
function mutations in SLC30A10, a cell surface–localized manganese efflux transporter in
the brain and liver, induce familial manganese neurotoxicity. To elucidate the role of
SLC30A10 in regulating brain manganese, we compared the phenotypes of whole-body
and tissue-specific Slc30a10 knockout mice. Surprisingly, unlike whole-body knockouts …