Dystonia with brain manganese accumulation resulting from SLC30A10 mutations: A new treatable disorder
M Stamelou, K Tuschl, WK Chong… - Movement …, 2012 - Wiley Online Library
Movement Disorders, 2012•Wiley Online Library
Background: The first gene causing early‐onset generalized dystonia with brain manganese
accumulation has recently been identified. Mutations in the SLC30A10 gene, encoding a
manganese transporter, cause a syndrome of hepatic cirrhosis, dystonia, polycythemia, and
hypermanganesemia. Methods: We present 10‐year longitudinal clinical features, MRI data,
and treatment response to chelation therapy of the originally described patient with a proven
homozygous mutation in SLC30A10. Results: The patient presented with early‐onset …
accumulation has recently been identified. Mutations in the SLC30A10 gene, encoding a
manganese transporter, cause a syndrome of hepatic cirrhosis, dystonia, polycythemia, and
hypermanganesemia. Methods: We present 10‐year longitudinal clinical features, MRI data,
and treatment response to chelation therapy of the originally described patient with a proven
homozygous mutation in SLC30A10. Results: The patient presented with early‐onset …
Background
The first gene causing early‐onset generalized dystonia with brain manganese accumulation has recently been identified. Mutations in the SLC30A10 gene, encoding a manganese transporter, cause a syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia.
Methods
We present 10‐year longitudinal clinical features, MRI data, and treatment response to chelation therapy of the originally described patient with a proven homozygous mutation in SLC30A10.
Results
The patient presented with early‐onset generalized dystonia and mild hyperbilirubinemia accompanied by elevated whole‐blood manganese levels. T1‐sequences in MRI showed hyperintensities in the basal ganglia and cerebellum, characteristic of manganese deposition. Treatment with intravenous disodium calcium edetate led to clinical improvement and reduction of hyperintensities in brain imaging.
Conclusions
We wish to highlight this rare disorder, which, together with Wilson's disease, is the only potentially treatable inherited metal storage disorder to date, that otherwise can be fatal as a result of complications of cirrhosis. © 2012 Movement Disorder Society
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