[HTML][HTML] Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice
S Hutchens, C Liu, T Jursa, W Shawlot… - Journal of Biological …, 2017 - ASBMB
Manganese is an essential metal that becomes toxic at elevated levels. Loss-of-function
mutations in SLC30A10, a cell-surface-localized manganese efflux transporter, cause a
heritable manganese metabolism disorder resulting in elevated manganese levels and
parkinsonian-like movement deficits. The underlying disease mechanisms are unclear;
therefore, treatment is challenging. To understand the consequences of loss of SLC30A10
function at the organism level, we generated Slc30a10 knock-out mice. During early …
mutations in SLC30A10, a cell-surface-localized manganese efflux transporter, cause a
heritable manganese metabolism disorder resulting in elevated manganese levels and
parkinsonian-like movement deficits. The underlying disease mechanisms are unclear;
therefore, treatment is challenging. To understand the consequences of loss of SLC30A10
function at the organism level, we generated Slc30a10 knock-out mice. During early …