Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis
K Kudo, T Uchida, M Sawada, Y Nakamura… - Advances in biological …, 2016 - Elsevier
Macrophages are key players in the innate immune response. Turnover of
phosphoinositides (PI), particularly phosphatidylinositol 4, 5 bisphosphate (PI (4, 5) P 2), has
been implicated in macrophage functions such as toll-like receptor (TLR)-mediated cytokine
production and phagocytosis. However, PI metabolizing enzymes responsible for
macrophage functions are not well defined. The phospholipase C (PLC) family of enzymes
is critical in PI (4, 5) P 2 turnover. In this study, we investigated the role of PLCδ1, a prototype …
phosphoinositides (PI), particularly phosphatidylinositol 4, 5 bisphosphate (PI (4, 5) P 2), has
been implicated in macrophage functions such as toll-like receptor (TLR)-mediated cytokine
production and phagocytosis. However, PI metabolizing enzymes responsible for
macrophage functions are not well defined. The phospholipase C (PLC) family of enzymes
is critical in PI (4, 5) P 2 turnover. In this study, we investigated the role of PLCδ1, a prototype …