Modeling aging in HIV infection in nonhuman primates to address an emerging challenge of the post-ART era
T He, E Falwell, E Brocca-Cofano, I Pandrea - Current opinion in virology, 2017 - Elsevier
Highlights•Aging is an emerging issue in the HIV-infected population in the post-ART
era.•Aging and HIV infection synergistically drive AIDS and non-AIDS comorbidities.•Rare
cases of AIDS progression in SIV natural hosts only occur in aged animals.•NHPs represent
an ideal model of aging and comorbidities in HIV infection.The advent of antiretroviral
therapy (ART) has dramatically improved both quality and length of life for subjects infected
with human immunodeficiency virus (HIV), delaying or preventing progression to acquired …
era.•Aging and HIV infection synergistically drive AIDS and non-AIDS comorbidities.•Rare
cases of AIDS progression in SIV natural hosts only occur in aged animals.•NHPs represent
an ideal model of aging and comorbidities in HIV infection.The advent of antiretroviral
therapy (ART) has dramatically improved both quality and length of life for subjects infected
with human immunodeficiency virus (HIV), delaying or preventing progression to acquired …