The transcription factor FOXM1 (Forkhead box M1): proliferation-specific expression, transcription factor function, target genes, mouse models, and normal biological …
I Wierstra - Advances in cancer research, 2013 - Elsevier
Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern.
Accordingly, both the expression and the transcriptional activity of FOXM1 are increased by
proliferation signals, but decreased by antiproliferation signals, including the positive and
negative regulation by protooncoproteins or tumor suppressors, respectively. FOXM1
stimulates cell cycle progression by promoting the entry into S-phase and M-phase …
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern.
Accordingly, both the expression and the transcriptional activity of FOXM1 are increased by
proliferation signals, but decreased by antiproliferation signals, including the positive and
negative regulation by protooncoproteins or tumor suppressors, respectively. FOXM1
stimulates cell cycle progression by promoting the entry into S-phase and M-phase …
