Mechanism of tumor cell-induced T-cell apoptosis mediated by galectin-1
F Kovács-Sólyom, A Blaskó, R Fajka-Boja, RL Katona… - Immunology letters, 2010 - Elsevier
Galectin-1 (Gal-1) has been implicated in tumor progression partly via the induction of T-cell
apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using
recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism
of Gal-1 and hence tumor cell-induced T-cell death, we applied co-cultures of tumor cells
and T-cells thus avoiding artificial circumstances generated using recombinant protein. T-
cells died when co-cultured with Gal-1-expressing but survived with Gal-1 non-expressing …
apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using
recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism
of Gal-1 and hence tumor cell-induced T-cell death, we applied co-cultures of tumor cells
and T-cells thus avoiding artificial circumstances generated using recombinant protein. T-
cells died when co-cultured with Gal-1-expressing but survived with Gal-1 non-expressing …