Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought
RM Pluta, J Hansen-Schwartz, J Dreier… - Neurological …, 2009 - Taylor & Francis
RM Pluta, J Hansen-Schwartz, J Dreier, P Vajkoczy, RL Macdonald, S Nishizawa, H Kasuya…
Neurological research, 2009•Taylor & FrancisObjective: Delayed cerebral vasospasm has long been recognized as an important cause of
poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm,
but it remains a pathophysiological enigma despite intensive research for more than half a
century. Method: Summarized in this review are highlights of research from North America,
Europe and Asia reflecting recent advances in the understanding of delayed ischemic
deficit. Result: It will focus on current accepted mechanisms and on new frontiers in …
poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm,
but it remains a pathophysiological enigma despite intensive research for more than half a
century. Method: Summarized in this review are highlights of research from North America,
Europe and Asia reflecting recent advances in the understanding of delayed ischemic
deficit. Result: It will focus on current accepted mechanisms and on new frontiers in …
Abstract
Objective: Delayed cerebral vasospasm has long been recognized as an important cause of poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm, but it remains a pathophysiological enigma despite intensive research for more than half a century.
Method: Summarized in this review are highlights of research from North America, Europe and Asia reflecting recent advances in the understanding of delayed ischemic deficit.
Result: It will focus on current accepted mechanisms and on new frontiers in vasospasm research.
Conclusion: A key issue is the recognition of events other than arterial narrowing such as early brain injury and cortical spreading depression and of their contribution to overall mortality and morbidity.
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