[HTML][HTML] Parathyroid hormone (1–34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A–CRTC3 signaling
FR Ricarte, C Le Henaff, VG Kolupaeva… - Journal of Biological …, 2018 - ASBMB
Osteoporosis can result from the loss of sex hormones and/or aging. Abaloparatide (ABL),
an analog of parathyroid hormone–related protein (PTHrP (1–36)), is the second
osteoanabolic therapy approved by the United States Food and Drug Administration after
teriparatide (PTH (1–34)). All three peptides bind PTH/PTHrP receptor type 1 (PTHR1), but
the effects of PTHrP (1–36) or ABL in the osteoblast remain unclear. We show that, in
primary calvarial osteoblasts, PTH (1–34) promotes a more robust cAMP response than …
an analog of parathyroid hormone–related protein (PTHrP (1–36)), is the second
osteoanabolic therapy approved by the United States Food and Drug Administration after
teriparatide (PTH (1–34)). All three peptides bind PTH/PTHrP receptor type 1 (PTHR1), but
the effects of PTHrP (1–36) or ABL in the osteoblast remain unclear. We show that, in
primary calvarial osteoblasts, PTH (1–34) promotes a more robust cAMP response than …