[HTML][HTML] VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells

AJ Khan, SM Misenko, A Thandoni, D Schiff… - Oncotarget, 2018 - ncbi.nlm.nih.gov
AJ Khan, SM Misenko, A Thandoni, D Schiff, SR Jhawar, SF Bunting, BG Haffty
Oncotarget, 2018ncbi.nlm.nih.gov
VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential
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Abstract
Purpose
DNA double-strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homologous recombination (HR). We demonstrate the selectivity of VX-984, a DNA-PK inhibitor, using assays not previously reported.
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