Intradermal (ID) BCG injection provides incomplete protection against TB in humans and
experimental models. Alternative BCG vaccination strategies may improve protection in
model species, including rhesus macaques. This study compares the immunogenicity and
efficacy of BCG administered by ID and intravenous (IV) injection, or as an intratracheal
mucosal boost (ID+ IT), against aerosol challenge with Mycobacterium tuberculosis Erdman
strain. Disease pathology was significantly reduced, and survival improved, by each BCG …