Screening of several H-2 congenic mouse strains identified H-2q mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement

KB Abdul-Majid, J Jirholt, C Stadelmann… - Journal of …, 2000 - Elsevier
We identified H-2q as a susceptible genotype for MOG-induced EAE by systematic
screening of a series of H-2 congenic B10 mouse strains. A series of H-2q-bearing strains
with divergent gene backgrounds were subsequently investigated. DBA/1 mice were highly
susceptible to MOG1–125-and MOG79–96-induced EAE in the absence of pertussis toxin.
Immunisation with MOG1–125 and MOG79–96 induced an autoreactive T-cell response in
DBA/1 mice. Brain histopathology revealed T-cell and macrophage-infiltrated lesions with …