Vitamin B12 absorption: mammalian physiology and acquired and inherited disorders

R Kozyraki, O Cases - Biochimie, 2013 - Elsevier
BACKGROUND: Vitamin B12 (cobalamin) is a cobalt-containing compound synthesized by
bacteria and an essential nutrient in mammals, which take it up from diet. The absorption
and distribution of dietary vitamin B12 to the organism is a complex process involving
several gene products including carrier proteins, plasma membrane receptors and
transporters. Disturbed cellular entry, transit or egress of vitamin B12 may lead to low vitamin
B12 status or deficiency and eventually hematological and neurological disorders …