Locus coeruleus volume and cell population changes during Alzheimer's disease progression: a stereological study in human postmortem brains with potential …
Introduction Alzheimer's disease (AD) progression follows a specific spreading pattern,
emphasizing the need to characterize those brain areas that degenerate first. The
brainstem's locus coeruleus (LC) is the first area to develop neurofibrillary changes
(neurofibrillary tangles [NFTs]). Methods The methods include unbiased stereological
analyses in human brainstems to estimate LC volume and neuronal population in controls
and individuals across all AD stages. Results As the Braak stage increases by 1 unit, the LC …
emphasizing the need to characterize those brain areas that degenerate first. The
brainstem's locus coeruleus (LC) is the first area to develop neurofibrillary changes
(neurofibrillary tangles [NFTs]). Methods The methods include unbiased stereological
analyses in human brainstems to estimate LC volume and neuronal population in controls
and individuals across all AD stages. Results As the Braak stage increases by 1 unit, the LC …