Translational regulation mechanisms of AP-1 proteins

PW Vesely, PB Staber, G Hoefler, L Kenner - Mutation Research/Reviews …, 2009 - Elsevier
The activator protein 1 (AP-1) transcription factor is assembled from jun-jun, jun-fos, or jun-
atf family protein homo-or heterodimers. AP-1 belongs to the class of basic leucine zipper
(bZIP) transcription factors. It binds to promoters of its target genes in a sequence-specific
manner, and transactivates or represses them. AP-1 proteins are implicated in the regulation
of a variety of cellular processes including proliferation and survival, differentiation, growth,
apoptosis, cell migration, and transformation. The decision if a given AP-1 factor is positively …