[HTML][HTML] Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil

MB Fessler, PG Arndt, SC Frasch, JG Lieber… - Journal of Biological …, 2004 - ASBMB
Lipid rafts are cholesterol-rich membrane microdomains that are thought to act as
coordinated signaling platforms by regulating dynamic, agonist-induced translocation of
signaling proteins. They have been described to play a role in multiple prototypical
cascades, among them the lipopolysaccharide pathway, and to host multiple signaling
proteins, including kinases and low molecular weight G-proteins. Here we report
lipopolysaccharide-induced activation of the Rho family GTPase Cdc42, and we show its …