The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death
Dysregulation of class I major histocompatibility (MHC1) expression is an important
mechanism of immunologic resistance for certain virus-infected or neoplastic cells. This
study characterizes a new molecule affecting MHC1 expression and CTL cytotoxicity.
Epithelial membrane protein 2 (EMP2) is a tetraspan protein recently identified for its role in
suppressing B lymphoma tumorigenicity. The biochemistry of EMP2 suggests that it
regulates the surface expression of certain membrane proteins, notably those destined for …
mechanism of immunologic resistance for certain virus-infected or neoplastic cells. This
study characterizes a new molecule affecting MHC1 expression and CTL cytotoxicity.
Epithelial membrane protein 2 (EMP2) is a tetraspan protein recently identified for its role in
suppressing B lymphoma tumorigenicity. The biochemistry of EMP2 suggests that it
regulates the surface expression of certain membrane proteins, notably those destined for …