Evolution and function of the TCR Vgamma9 chain repertoire: It's good to be public
CD Pauza, C Cairo - Cellular immunology, 2015 - Elsevier
Lymphocytes expressing a T cell receptor (TCR) composed of Vgamma9 and Vdelta2
chains represent a minor fraction of human thymocytes. Extrathymic selection throughout
post-natal life causes the proportion of cells with a Vgamma9–JP rearrangement to increase
and elevates the capacity for responding to non-peptidic phosphoantigens. Extrathymic
selection is so powerful that phosphoantigen-reactive cells comprise about 1 in 40
circulating memory T cells in healthy adults and the subset expands rapidly upon infection or …
chains represent a minor fraction of human thymocytes. Extrathymic selection throughout
post-natal life causes the proportion of cells with a Vgamma9–JP rearrangement to increase
and elevates the capacity for responding to non-peptidic phosphoantigens. Extrathymic
selection is so powerful that phosphoantigen-reactive cells comprise about 1 in 40
circulating memory T cells in healthy adults and the subset expands rapidly upon infection or …