Sweet connections: O-GlcNAcylation links cancer cell metabolism and survival

CM Ferrer, MJ Reginato - Molecular & Cellular Oncology, 2015 - Taylor & Francis
Molecular & Cellular Oncology, 2015Taylor & Francis
Increased O-GlcNAcylation is emerging as a general characteristic of cancer cells that is
critical for multiple oncogenic phenotypes. Recently, we demonstrated that elevated O-
GlcNAcylation contributes to the metabolic shift seen in cancer through stabilization of the
glycolytic regulator HIF-1α and links metabolism to stress and cancer cell survival.
Increased O-GlcNAcylation is emerging as a general characteristic of cancer cells that is critical for multiple oncogenic phenotypes. Recently, we demonstrated that elevated O-GlcNAcylation contributes to the metabolic shift seen in cancer through stabilization of the glycolytic regulator HIF-1α and links metabolism to stress and cancer cell survival.
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