Clinical manifestations and beta cell function in Swedish diabetic children have remained unchanged during the last 25 years
M Nordwall, J Ludvigsson1 - Diabetes/metabolism research …, 2008 - Wiley Online Library
M Nordwall, J Ludvigsson1
Diabetes/metabolism research and reviews, 2008•Wiley Online LibraryBackground The incidence of type 1 diabetes in childhood has doubled in Sweden during
the last decades. Environmental factors may cause a different disease process, residual
beta cell function and clinical manifestation. Insulin therapy has become more intensive. The
aim of this study was to examine the clinical characteristics at onset, C-peptide secretion
during the first years after diagnosis and if there was any secular trends during the last 25
years. Methods All 316 children diagnosed with type 1 diabetes during 1976–2000 and …
the last decades. Environmental factors may cause a different disease process, residual
beta cell function and clinical manifestation. Insulin therapy has become more intensive. The
aim of this study was to examine the clinical characteristics at onset, C-peptide secretion
during the first years after diagnosis and if there was any secular trends during the last 25
years. Methods All 316 children diagnosed with type 1 diabetes during 1976–2000 and …
Abstract
Background The incidence of type 1 diabetes in childhood has doubled in Sweden during the last decades. Environmental factors may cause a different disease process, residual beta cell function and clinical manifestation. Insulin therapy has become more intensive. The aim of this study was to examine the clinical characteristics at onset, C-peptide secretion during the first years after diagnosis and if there was any secular trends during the last 25 years.
Methods All 316 children diagnosed with type 1 diabetes during 1976–2000 and living in the Linköping area were included. Information about clinical characteristics at diagnosis, duration of partial remission, insulin therapy at diagnosis and during the first years was collected from medical records. C-peptide secretion (fasting and stimulated) was measured regularly during the first 5 years. For analysis, the population was divided in five cohorts according to the year of diagnosis.
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