Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease
JL Mega, W Hochholzer, AL Frelinger, MJ Kluk… - Jama, 2011 - jamanetwork.com
Context Variants in the CYP2C19 gene influence the pharmacologic and clinical response
to the standard 75-mg daily maintenance dose of the antiplatelet drug clopidogrel. Objective
To test whether higher doses (up to 300 mg daily) improve the response to clopidogrel in the
setting of loss-of-function CYP2C19 genotypes. Design, Setting, and Patients ELEVATE-TIMI
56 was a multicenter, randomized, double-blind trial that enrolled and genotyped 333
patients with cardiovascular disease across 32 sites from October 2010 until September …
to the standard 75-mg daily maintenance dose of the antiplatelet drug clopidogrel. Objective
To test whether higher doses (up to 300 mg daily) improve the response to clopidogrel in the
setting of loss-of-function CYP2C19 genotypes. Design, Setting, and Patients ELEVATE-TIMI
56 was a multicenter, randomized, double-blind trial that enrolled and genotyped 333
patients with cardiovascular disease across 32 sites from October 2010 until September …