[HTML][HTML] Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes
M Matsuda-Lennikov, M Biancalana, J Zou… - Journal of Biological …, 2019 - ASBMB
Magnesium transporter 1 (MAGT1) critically mediates magnesium homeostasis in
eukaryotes and is highly-conserved across different evolutionary branches. In humans, loss–
of–function mutations in the MAGT1 gene cause X-linked magnesium deficiency with
Epstein-Barr virus (EBV) infection and neoplasia (XMEN), a disease that has a broad range
of clinical and immunological consequences. We have previously shown that EBV
susceptibility in XMEN is associated with defective expression of the antiviral natural-killer …
eukaryotes and is highly-conserved across different evolutionary branches. In humans, loss–
of–function mutations in the MAGT1 gene cause X-linked magnesium deficiency with
Epstein-Barr virus (EBV) infection and neoplasia (XMEN), a disease that has a broad range
of clinical and immunological consequences. We have previously shown that EBV
susceptibility in XMEN is associated with defective expression of the antiviral natural-killer …