Global analysis of lymphoma genome integrity and transcriptomes tremendously advanced
our understanding of their biology. Technological advances in mass spectrometry-based
proteomics promise to complete the picture by allowing the global quantification of proteins
and their post-translational modifications. Here we use N-glyco FASP, a recently developed
mass spectrometric approach using lectin-enrichment, in conjunction with a super-SILAC
approach to quantify N-linked glycoproteins in lymphoma cells. From patient-derived diffuse …