[HTML][HTML] Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants [S]
JM Lee, JR Ong, L Vergnes, TQ de Aguiar Vallim… - Journal of lipid …, 2018 - ASBMB
Diet1 modulates intestinal production of the hormone, fibroblast growth factor (FGF) 15,
which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous
Diet1-null mutation are resistant to hypercholesterolemia compared with wild-type C57BL/6J
mice through enhanced cholesterol conversion to bile acids. To further characterize the role
of Diet1 in metabolism, we generated Diet1−/− mice on the C57BL/6J genetic background.
C57BL/6J Diet1−/− mice had elevated bile acid levels, reduced Fgf15 expression, and …
which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous
Diet1-null mutation are resistant to hypercholesterolemia compared with wild-type C57BL/6J
mice through enhanced cholesterol conversion to bile acids. To further characterize the role
of Diet1 in metabolism, we generated Diet1−/− mice on the C57BL/6J genetic background.
C57BL/6J Diet1−/− mice had elevated bile acid levels, reduced Fgf15 expression, and …