The emergence of TH17 cells as effectors of renal injury
AR Kitching, SR Holdsworth - Journal of the American Society of …, 2011 - journals.lww.com
Abstract IL-17–producing Th17 effector cells directly induce renal inflammation by activating
neutrophils or by participating in macrophage-mediated tissue injury. Th17 cells and
cytokines participate in human and experimental renal disease, especially in proliferative
glomerulonephritis where Th17 effector cells are active. Although growing evidence
suggests Th17 cells are particularly relevant to effector responses involving neutrophils,
there are still important questions to address before the complete functions of Th17 cells in …
neutrophils or by participating in macrophage-mediated tissue injury. Th17 cells and
cytokines participate in human and experimental renal disease, especially in proliferative
glomerulonephritis where Th17 effector cells are active. Although growing evidence
suggests Th17 cells are particularly relevant to effector responses involving neutrophils,
there are still important questions to address before the complete functions of Th17 cells in …