Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control
AR Hersperger, SA Migueles, MR Betts… - Current Opinion in HIV …, 2011 - journals.lww.com
Current Opinion in HIV and AIDS, 2011•journals.lww.com
Investigation from multiple groups has now focused upon HIV-specific CD8+ T-cell granule-
exocytosis-mediated cytotoxicity as a correlate of immunologic control of HIV. In the near
future, a more detailed understanding of the qualities associated with immunologic control
may provide critical insights regarding the necessary features of a response that should be
stimulated by immunotherapies or T-cell-based vaccines.
exocytosis-mediated cytotoxicity as a correlate of immunologic control of HIV. In the near
future, a more detailed understanding of the qualities associated with immunologic control
may provide critical insights regarding the necessary features of a response that should be
stimulated by immunotherapies or T-cell-based vaccines.
Summary
Investigation from multiple groups has now focused upon HIV-specific CD8+ T-cell granule-exocytosis-mediated cytotoxicity as a correlate of immunologic control of HIV. In the near future, a more detailed understanding of the qualities associated with immunologic control may provide critical insights regarding the necessary features of a response that should be stimulated by immunotherapies or T-cell-based vaccines.
Lippincott Williams & Wilkins