Detection of immunoglobulin gene rearrangement of B cell non-Hodgkin's lymphomas and leukemias in fresh, unfixed and formalin-fixed, paraffin-embedded tissue by …
G Inghirami, MJ Szabolcs, HT Yee… - … ; a journal of technical …, 1993 - europepmc.org
G Inghirami, MJ Szabolcs, HT Yee, P Corradini, E Cesarman, DM Knowles
Laboratory investigation; a journal of technical methods and pathology, 1993•europepmc.orgBackground The majority of B cell nonHodgkin's lymphomas (NHLs) are composed of a
genotypically identical cell population characterized by a unique immunoglobulin (Ig) VDJ
gene rearrangement which is customarily documented by Southern blot hybridization
analysis of fresh tissue. Sometimes, however, this approach cannot be used because of an
insufficient quantity of tissue or the unavailability of fresh tissue. Therefore, alternative
strategies should be designed in order to overcome these limitations.
genotypically identical cell population characterized by a unique immunoglobulin (Ig) VDJ
gene rearrangement which is customarily documented by Southern blot hybridization
analysis of fresh tissue. Sometimes, however, this approach cannot be used because of an
insufficient quantity of tissue or the unavailability of fresh tissue. Therefore, alternative
strategies should be designed in order to overcome these limitations.
Background
The majority of B cell nonHodgkin's lymphomas (NHLs) are composed of a genotypically identical cell population characterized by a unique immunoglobulin (Ig) VDJ gene rearrangement which is customarily documented by Southern blot hybridization analysis of fresh tissue. Sometimes, however, this approach cannot be used because of an insufficient quantity of tissue or the unavailability of fresh tissue. Therefore, alternative strategies should be designed in order to overcome these limitations.
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