[HTML][HTML] FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells
GM Wochnik, J Ruegg, GA Abel, U Schmidt… - Journal of Biological …, 2005 - ASBMB
We used a cellular system to elucidate the molecular determinants of the large immunophilin
FK506-binding proteins (FKBP) 51 and-52 for their action on the glucocorticoid receptor in
mammalian cells. Increasing the levels of FKBP51 reduced the transcriptional activity of the
receptor, as reported. Elevated levels of FKBP52 per se showed no effect but mitigated the
inhibition of the receptor induced by FKBP51. We discovered that nuclear translocation of
the glucocorticoid receptor was delayed by FKBP51. This correlates with the reduced …
FK506-binding proteins (FKBP) 51 and-52 for their action on the glucocorticoid receptor in
mammalian cells. Increasing the levels of FKBP51 reduced the transcriptional activity of the
receptor, as reported. Elevated levels of FKBP52 per se showed no effect but mitigated the
inhibition of the receptor induced by FKBP51. We discovered that nuclear translocation of
the glucocorticoid receptor was delayed by FKBP51. This correlates with the reduced …
