The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease

RH Oakley, JA Cidlowski - Journal of Allergy and Clinical Immunology, 2013 - Elsevier
Glucocorticoids are primary stress hormones necessary for life that regulate numerous
physiologic processes in an effort to maintain homeostasis. Synthetic derivatives of these
hormones have been mainstays in the clinic for treating inflammatory diseases, autoimmune
disorders, and hematologic cancers. The physiologic and pharmacologic actions of
glucocorticoids are mediated by the glucocorticoid receptor (GR), a member of the nuclear
receptor superfamily of ligand-dependent transcription factors. Ligand-occupied GR induces …