Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder
R Yehuda, JA Golier, RK Yang, L Tischler - Biological psychiatry, 2004 - Elsevier
BACKGROUND: The aim of this study was to determine whether there is increased
responsiveness to corticosteroids in posttraumatic stress disorder (PTSD) by examining the
differential effects of dexamethasone (DEX) on the inhibition of lysozyme activity.
METHODS: 60 mL of blood was withdrawn at 8: 00 am, and mononuclear leukocytes were
isolated from the blood of 26 men with, and 18 men without, PTSD. An aliquot of live cells
was incubated with a series of concentrations of DEX to determine the rate of inhibition of …
responsiveness to corticosteroids in posttraumatic stress disorder (PTSD) by examining the
differential effects of dexamethasone (DEX) on the inhibition of lysozyme activity.
METHODS: 60 mL of blood was withdrawn at 8: 00 am, and mononuclear leukocytes were
isolated from the blood of 26 men with, and 18 men without, PTSD. An aliquot of live cells
was incubated with a series of concentrations of DEX to determine the rate of inhibition of …