[HTML][HTML] C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90

J Cheung-Flynn, PJ Roberts, DL Riggs… - Journal of Biological …, 2003 - ASBMB
Hsp90 assembles with steroid receptors and other client proteins in association with one or
more Hsp90-binding cochaperones, some of which contain a common tetratricopeptide
repeat (TPR) domain. Included in the TPR cochaperones are the Hsp70-Hsp90-organizing
protein Hop, the FK506-binding immunophilins FKBP52 and FKBP51, the cyclosporin A-
binding immunophilin CyP40, and protein phosphatase PP5. The TPR domains from these
proteins have similar x-ray crystallographic structures and target cochaperone binding to the …