Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels
M Schedel, S Michel, VD Gaertner, AA Toncheva… - Journal of Allergy and …, 2015 - Elsevier
Background Chromosome 17q21, harboring the orosomucoid 1-like 3 (ORMDL3) gene, has
been consistently associated with childhood asthma in genome-wide association studies.
Objective We investigated genetic variants in and around ORMDL3 that can change the
function of ORMDL3 and thus contribute to asthma susceptibility. Methods We performed
haplotype analyses and fine mapping of the ORMDL3 locus in a cross-sectional
(International Study of Asthma and Allergies in Childhood Phase II, n= 3557 total subjects …
been consistently associated with childhood asthma in genome-wide association studies.
Objective We investigated genetic variants in and around ORMDL3 that can change the
function of ORMDL3 and thus contribute to asthma susceptibility. Methods We performed
haplotype analyses and fine mapping of the ORMDL3 locus in a cross-sectional
(International Study of Asthma and Allergies in Childhood Phase II, n= 3557 total subjects …