[HTML][HTML] Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease
S Löser, LG Gregory, Y Zhang, K Schaefer… - Journal of Allergy and …, 2017 - Elsevier
Background Genome-wide association studies have identified the ORM (yeast)-like protein
isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk
factor for childhood-onset asthma. Objective We sought to investigate in vivo the functional
role of ORMDL3 in disease inception. Methods An Ormdl3-deficient mouse was generated
and the role of ORMDL3 in the generation of allergic airways disease to the fungal
aeroallergen Alternaria alternata was determined. An adeno-associated viral vector was …
isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk
factor for childhood-onset asthma. Objective We sought to investigate in vivo the functional
role of ORMDL3 in disease inception. Methods An Ormdl3-deficient mouse was generated
and the role of ORMDL3 in the generation of allergic airways disease to the fungal
aeroallergen Alternaria alternata was determined. An adeno-associated viral vector was …