Background: Adjustments of carbohydrate intake and oxidation occur in both normal-weight
and overweight individuals. Nevertheless, the contribution of carbohydrates to the
accumulation of fat through either reduction of fat oxidation or stimulation of fat synthesis in
obesity remains poorly investigated. Objective: The objective of this study was to assess the
postprandial metabolic changes and the fractional hepatic de novo lipogenesis (DNL)
induced by a high-carbohydrate, low-fat meal in lean and overweight young men. Design: A …