[HTML][HTML] Fasting hepatic de novo lipogenesis is not reliably assessed using circulating fatty acid markers
F Rosqvist, CA McNeil, C Pramfalk, SA Parry… - The American journal of …, 2019 - Elsevier
Background Observational studies often infer hepatic de novo lipogenesis (DNL) by
measuring circulating fatty acid (FA) markers; however, it remains to be elucidated whether
these markers accurately reflect hepatic DNL. Objective We investigated associations
between fasting hepatic DNL and proposed FA markers of DNL in subjects consuming their
habitual diet. Methods Fasting hepatic DNL was assessed using 2 H 2 O (deuterated water)
in 149 nondiabetic men and women and measuring the synthesis of very low-density …
measuring circulating fatty acid (FA) markers; however, it remains to be elucidated whether
these markers accurately reflect hepatic DNL. Objective We investigated associations
between fasting hepatic DNL and proposed FA markers of DNL in subjects consuming their
habitual diet. Methods Fasting hepatic DNL was assessed using 2 H 2 O (deuterated water)
in 149 nondiabetic men and women and measuring the synthesis of very low-density …