[HTML][HTML] Galiellalactone Is a Direct Inhibitor of the Transcription Factor STAT3 in Prostate Cancer Cells*♦
N Don-Doncow, Z Escobar, M Johansson… - Journal of Biological …, 2014 - ASBMB
The transcription factor STAT3 is constitutively active in several malignancies including
castration-resistant prostate cancer and has been identified as a promising therapeutic
target. The fungal metabolite galiellalactone, a STAT3 signaling inhibitor, inhibits the growth,
both in vitro and in vivo, of prostate cancer cells expressing active STAT3 and induces
apoptosis of prostate cancer stem cell-like cells expressing phosphorylated STAT3
(pSTAT3). However, the molecular mechanism of this STAT3-inhibiting effect by …
castration-resistant prostate cancer and has been identified as a promising therapeutic
target. The fungal metabolite galiellalactone, a STAT3 signaling inhibitor, inhibits the growth,
both in vitro and in vivo, of prostate cancer cells expressing active STAT3 and induces
apoptosis of prostate cancer stem cell-like cells expressing phosphorylated STAT3
(pSTAT3). However, the molecular mechanism of this STAT3-inhibiting effect by …