Natural killer cells acquire CD73 expression upon exposure to mesenchymal stem cells
D Chatterjee, DM Tufa, H Baehre… - Blood, The Journal …, 2014 - ashpublications.org
D Chatterjee, DM Tufa, H Baehre, R Hass, RE Schmidt, R Jacobs
Blood, The Journal of the American Society of Hematology, 2014•ashpublications.orgWe read with great interest the article by Saze et al, 1 which was published recently in Blood
as a plenary paper. The authors illustrated that human peripheral blood B cells express
ectonucleotidases CD39 and CD73. Thus, B cells are capable of hydrolyzing adenosine
triphosphate to adenosine 59-monophosphate (59-AMP) via CD39 and subsequently to
adenosine (ADO) by means of CD73 enzymatic activity. In our laboratory, we study the
interaction between human natural killer (NK) cells and mesenchymal stem cells (MSCs) …
as a plenary paper. The authors illustrated that human peripheral blood B cells express
ectonucleotidases CD39 and CD73. Thus, B cells are capable of hydrolyzing adenosine
triphosphate to adenosine 59-monophosphate (59-AMP) via CD39 and subsequently to
adenosine (ADO) by means of CD73 enzymatic activity. In our laboratory, we study the
interaction between human natural killer (NK) cells and mesenchymal stem cells (MSCs) …
We read with great interest the article by Saze et al, 1 which was published recently in Blood as a plenary paper. The authors illustrated that human peripheral blood B cells express ectonucleotidases CD39 and CD73. Thus, B cells are capable of hydrolyzing adenosine triphosphate to adenosine 59-monophosphate (59-AMP) via CD39 and subsequently to adenosine (ADO) by means of CD73 enzymatic activity.
In our laboratory, we study the interaction between human natural killer (NK) cells and mesenchymal stem cells (MSCs). Due to their immunosuppressive properties and inherent immunopriviledged nature, MSCs can be used as biological tolerance inducers in inflammatory and autoimmune diseases. 2, 3 In this work, we cocultured fluorescence-activated cell sorter (FACS)-sorted allogeneic NK cells
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