[HTML][HTML] Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-κB and MAPKs
JE Towne, KE Garka, BR Renshaw, GD Virca… - Journal of Biological …, 2004 - ASBMB
Interleukin 1 (IL-1) plays a prominent role in immune and inflammatory reactions. Our
understanding of the IL-1 family has recently expanded to include six novel members named
IL-1F5 to IL-1F10. Recently, it was reported that IL-1F9 activated NF-κB through the orphan
receptor IL-1 receptor (IL-1R)-related protein 2 (IL-1Rrp2) in Jurkat cells (Debets, R., Timans,
JC, Homey, B., Zurawski, S., Sana, TR, Lo, S., Wagner, J., Edwards, G., Clifford, T., Menon,
S., Bazan, JF, and Kastelein, RA (2001) J. Immunol. 167, 1440–1446). In this study, we …
understanding of the IL-1 family has recently expanded to include six novel members named
IL-1F5 to IL-1F10. Recently, it was reported that IL-1F9 activated NF-κB through the orphan
receptor IL-1 receptor (IL-1R)-related protein 2 (IL-1Rrp2) in Jurkat cells (Debets, R., Timans,
JC, Homey, B., Zurawski, S., Sana, TR, Lo, S., Wagner, J., Edwards, G., Clifford, T., Menon,
S., Bazan, JF, and Kastelein, RA (2001) J. Immunol. 167, 1440–1446). In this study, we …