[HTML][HTML] Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors
J Perroy, F Raynaud, V Homburger, MC Rousset… - Journal of Biological …, 2008 - ASBMB
Functional interplay between ionotropic and metabotropic receptors frequently involves
complex intracellular signaling cascades. The group I metabotropic glutamate receptor
mGlu5a co-clusters with the ionotropic N-methyl-d-aspartate (NMDA) receptor in
hippocampal neurons. In this study, we report that a more direct cross-talk can exist between
these types of receptors. Using bioluminescence resonance energy transfer in living
HEK293 cells, we demonstrate that mGlu5a and NMDA receptor clustering reflects the …
complex intracellular signaling cascades. The group I metabotropic glutamate receptor
mGlu5a co-clusters with the ionotropic N-methyl-d-aspartate (NMDA) receptor in
hippocampal neurons. In this study, we report that a more direct cross-talk can exist between
these types of receptors. Using bioluminescence resonance energy transfer in living
HEK293 cells, we demonstrate that mGlu5a and NMDA receptor clustering reflects the …