Derangement of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and extracellular signal-regulated kinase (ERK) dependent striatal plasticity in L-DOPA …

M Cerovic, V Bagetta, V Pendolino, V Ghiglieri… - Biological …, 2015 - Elsevier
Background Bidirectional long-term plasticity at the corticostriatal synapse has been
proposed as a central cellular mechanism governing dopamine-mediated behavioral
adaptations in the basal ganglia system. Balanced activity of medium spiny neurons (MSNs)
in the direct and the indirect pathways is essential for normal striatal function. This balance is
disrupted in Parkinson's disease and in l-3, 4-dihydroxyphenylalanine (l-DOPA)-induced
dyskinesia (LID), a common motor complication of current pharmacotherapy of Parkinson's …