[HTML][HTML] Critical and direct involvement of the CD23 stalk region in IgE binding
R Selb, J Eckl-Dorna, TE Twaroch, C Lupinek… - Journal of Allergy and …, 2017 - Elsevier
Background The low-affinity receptor for IgE, FcεRII (CD23), contributes to allergic
inflammation through allergen presentation to T cells, regulation of IgE responses, and
enhancement of transepithelial allergen migration. Objective We sought to investigate the
interaction between CD23, chimeric monoclonal human IgE, and the corresponding birch
pollen allergen Bet v 1 at a molecular level. Methods We expressed 4 CD23 variants. One
variant comprised the full extracellular portion of CD23, including the stalk and head …
inflammation through allergen presentation to T cells, regulation of IgE responses, and
enhancement of transepithelial allergen migration. Objective We sought to investigate the
interaction between CD23, chimeric monoclonal human IgE, and the corresponding birch
pollen allergen Bet v 1 at a molecular level. Methods We expressed 4 CD23 variants. One
variant comprised the full extracellular portion of CD23, including the stalk and head …