Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia
H Taneichi, H Kanegane, MM Sira, T Futatani… - Clinical …, 2008 - Elsevier
Bruton's tyrosine kinase (BTK), which is defective in patients with X-linked
agammaglobulinemia (XLA), is expressed not only in B cells but also in monocytes and
dendritic cells (DCs). DCs play a crucial role in the innate immune response against
infections by sensing pathogens through Toll-like receptors (TLRs). However, it is not known
whether BTK deficiency in XLA might impair TLR-mediated signaling in DCs, which are
susceptible to various infections. The phenotypic maturation and cytokine production …
agammaglobulinemia (XLA), is expressed not only in B cells but also in monocytes and
dendritic cells (DCs). DCs play a crucial role in the innate immune response against
infections by sensing pathogens through Toll-like receptors (TLRs). However, it is not known
whether BTK deficiency in XLA might impair TLR-mediated signaling in DCs, which are
susceptible to various infections. The phenotypic maturation and cytokine production …