[HTML][HTML] Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection
L Liao, D Cheng, J Wang, DM Duong, TG Losik… - Journal of Biological …, 2004 - ASBMB
The presence of amyloid plaques in the brain is one of the pathological hallmarks of
Alzheimer's disease (AD). We report here a comprehensive proteomic analysis of senile
plaques from postmortem AD brain tissues. Senile plaques labeled with thioflavin-S were
procured by laser capture microdissection, and their protein components were analyzed by
liquid chromatography coupled with tandem mass spectrometry. We identified a total of 488
proteins coisolated with the plaques, and we found multiple phosphorylation sites on the …
Alzheimer's disease (AD). We report here a comprehensive proteomic analysis of senile
plaques from postmortem AD brain tissues. Senile plaques labeled with thioflavin-S were
procured by laser capture microdissection, and their protein components were analyzed by
liquid chromatography coupled with tandem mass spectrometry. We identified a total of 488
proteins coisolated with the plaques, and we found multiple phosphorylation sites on the …