Serum α-Fetoprotein in a Mouse Strain (C3H-Avy fB) with Spontaneous Hepatocellular Carcinomas
FF Becker, D Stillman, S Sell - Cancer Research, 1977 - AACR
FF Becker, D Stillman, S Sell
Cancer Research, 1977•AACRIn a study of the association between circulating α-fetoprotein concentrations and
spontaneous hepatocellular carcinomas, we examined C3H-Avy fB mice, which with age
consistently demonstrate a rapidly increasing incidence of hepatic cancer. Although
elevated α-fetoprotein levels are observed in association with the majority of these tumors,
no elevation of α-fetoprotein was observed during the life course of non-tumor-bearing mice
despite their age-dependent risk for hepatic cancer. Therefore, whatever the evolutionary or …
spontaneous hepatocellular carcinomas, we examined C3H-Avy fB mice, which with age
consistently demonstrate a rapidly increasing incidence of hepatic cancer. Although
elevated α-fetoprotein levels are observed in association with the majority of these tumors,
no elevation of α-fetoprotein was observed during the life course of non-tumor-bearing mice
despite their age-dependent risk for hepatic cancer. Therefore, whatever the evolutionary or …
Summary
In a study of the association between circulating α-fetoprotein concentrations and spontaneous hepatocellular carcinomas, we examined C3H-Avy fB mice, which with age consistently demonstrate a rapidly increasing incidence of hepatic cancer. Although elevated α-fetoprotein levels are observed in association with the majority of these tumors, no elevation of α-fetoprotein was observed during the life course of non-tumor-bearing mice despite their age-dependent risk for hepatic cancer. Therefore, whatever the evolutionary or age-related biological changes may be that lead to tumor formation in this mouse, they are not linked to the synthesis of significant amounts of this oncofetal protein.
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