Finding the will and the way of ERAD substrate retrotranslocation
RY Hampton, T Sommer - Current opinion in cell biology, 2012 - Elsevier
RY Hampton, T Sommer
Current opinion in cell biology, 2012•ElsevierER-associated degradation (ERAD) is a mechanism by which numerous ER-localized
proteins are targeted for cytosolic degradation by the ubiquitin–proteasome system. A
surprising and still-cryptic requirement of this process is the energy dependent
retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for
ongoing ubiquitination and proteasomal destruction. The current understanding, results, and
open questions are discussed below for this intriguing and critical process of ERAD.
proteins are targeted for cytosolic degradation by the ubiquitin–proteasome system. A
surprising and still-cryptic requirement of this process is the energy dependent
retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for
ongoing ubiquitination and proteasomal destruction. The current understanding, results, and
open questions are discussed below for this intriguing and critical process of ERAD.
ER-associated degradation (ERAD) is a mechanism by which numerous ER-localized proteins are targeted for cytosolic degradation by the ubiquitin–proteasome system. A surprising and still-cryptic requirement of this process is the energy dependent retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for ongoing ubiquitination and proteasomal destruction. The current understanding, results, and open questions are discussed below for this intriguing and critical process of ERAD.
Elsevier
