[HTML][HTML] MCP-1 is induced by receptor activator of nuclear factor-κB ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony …
MS Kim, CJ Day, NA Morrison - Journal of Biological Chemistry, 2005 - ASBMB
Human osteoclast formation from monocyte precursors under the action of receptor activator
of nuclear factor-κB ligand (RANKL) was suppressed by granulocyte macrophage colony-
stimulating factor (GM-CSF), with down-regulation of critical osteoclast-related nuclear
factors. GM-CSF in the presence of RANKL and macrophage colony-stimulating factor
resulted in mononuclear cells that were negative for tartrate-resistant acid phosphatase
(TRAP) and negative for bone resorption. CD1a, a dendritic cell marker, was expressed in …
of nuclear factor-κB ligand (RANKL) was suppressed by granulocyte macrophage colony-
stimulating factor (GM-CSF), with down-regulation of critical osteoclast-related nuclear
factors. GM-CSF in the presence of RANKL and macrophage colony-stimulating factor
resulted in mononuclear cells that were negative for tartrate-resistant acid phosphatase
(TRAP) and negative for bone resorption. CD1a, a dendritic cell marker, was expressed in …