[HTML][HTML] The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor-and CD14-dependent mechanism
Amphotericin B is the most effective drug for treating many life-threatening fungal infections.
Amphotericin B administration is limited by infusion-related toxicity, including fever and
chills, an effect postulated to result from proinflammatory cytokine production by innate
immune cells. Because amphotericin B is a microbial product, we hypothesized that it
stimulates immune cells via Toll-like receptors (TLRs) and CD14. We show here that
amphotericin B induces signal transduction and inflammatory cytokine release from cells …
Amphotericin B administration is limited by infusion-related toxicity, including fever and
chills, an effect postulated to result from proinflammatory cytokine production by innate
immune cells. Because amphotericin B is a microbial product, we hypothesized that it
stimulates immune cells via Toll-like receptors (TLRs) and CD14. We show here that
amphotericin B induces signal transduction and inflammatory cytokine release from cells …