[HTML][HTML] Determinants of the phagosomal pH in neutrophils
A Jankowski, CC Scott, S Grinstein - Journal of Biological Chemistry, 2002 - ASBMB
Phagosomes formed by neutrophils are much less acidic than those of other phagocytic
cells. The defective acidification seen in neutrophils has been attributed to consumption of
protons during the dismutation of superoxide, because a large, sustained acidification is
unmasked when the cells are treated with inhibitors of the NADPH oxidase. Consumption of
protons transported into the phagosome by dismutation would tightly couple the activities of
the NADPH oxidase and the vacuolar type H+-pump (or V-ATPase). We tested the existence …
cells. The defective acidification seen in neutrophils has been attributed to consumption of
protons during the dismutation of superoxide, because a large, sustained acidification is
unmasked when the cells are treated with inhibitors of the NADPH oxidase. Consumption of
protons transported into the phagosome by dismutation would tightly couple the activities of
the NADPH oxidase and the vacuolar type H+-pump (or V-ATPase). We tested the existence …