[HTML][HTML] Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles
J Kim, S Hamamoto, M Ravazzola, L Orci… - Journal of Biological …, 2005 - ASBMB
Mutant forms of presenilin (PS) 1 and 2 and amyloid precursor protein (APP) lead to familial
Alzheimer's disease. Several reports indicate that PS may modulate APP export from the
endoplasmic reticulum (ER). To develop a test of this possibility, we reconstituted the
capture of APP and PS1 in COPII (coat protein complex II) vesicles formed from ER
membranes in permeabilized cultured cells. The recombinant forms of mammalian COPII
proteins were active in a reaction that measures coat subunit assembly and coated vesicle …
Alzheimer's disease. Several reports indicate that PS may modulate APP export from the
endoplasmic reticulum (ER). To develop a test of this possibility, we reconstituted the
capture of APP and PS1 in COPII (coat protein complex II) vesicles formed from ER
membranes in permeabilized cultured cells. The recombinant forms of mammalian COPII
proteins were active in a reaction that measures coat subunit assembly and coated vesicle …
